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Infection and Immunity, July 2000, p. 4331-4334, Vol. 68, No. 7
0019-9567/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Pseudomonas aeruginosa Cell-to-Cell Signaling Is Required for Virulence in a Model of Acute Pulmonary Infection

James P. Pearson,1,dagger Matthew Feldman,2 Barbara H. Iglewski,1 and Alice Prince2,*

Department of Microbiology and Immunology, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642,1 and College of Physicians and Surgeons, Columbia University, New York, New York 100322

Received 22 December 1999/Returned for modification 24 March 2000/Accepted 29 March 2000

Cell-to-cell signaling controls many virulence genes in Pseudomonas aeruginosa. We tested the virulence of las and rhl quorum-sensing mutants in neonatal mice. A lasI rhlI double mutant was nearly avirulent, and the respective single mutant strains were reduced in virulence compared with the wild-type strain. Quorum sensing plays a role in P. aeruginosa pneumonia in neonatal mice.

* Corresponding author. Mailing address: College of Physicians and Surgeons, Columbia University, 650 W. 168th St., New York, NY 10032. Phone: (212) 305-4193. Fax: (212) 305-2284. E-mail: asp7{at}columbia.edu.

dagger Present address: Department of Microbiology, Protein Design Labs, Inc., Fremont, CA 94555.

Infection and Immunity, July 2000, p. 4331-4334, Vol. 68, No. 7
0019-9567/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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