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Infection and Immunity, July 2000, p. 4340-4343, Vol. 68, No. 7
0019-9567/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Host Resistance to Listeria monocytogenes Infection Is Enhanced but Resistance to Staphylococcus aureus Infection Is Reduced in Acute Graft-versus-Host Disease in Mice

Tomisato Miura,1,2 Daisuke Mizuki,1 Sanae Sasaki,1 Suguru Hasegawa,1 Hiroshi Sashinami,1 and Akio Nakane1,*

Department of Bacteriology, Hirosaki University School of Medicine,1 and School of Allied Medical Sciences, Hirosaki University,2 Hirosaki, Aomori, Japan

Received 20 January 2000/Returned for modification 1 March 2000/Accepted 12 April 2000

Acute graft-versus-host disease (GVHD) is characterized by the production of high levels of T helper 1 (Th1)-type cytokines. Bone marrow transplantation from allogeneic C57BL/6 cells to CBF1 mice produced acute GVHD. Host resistance to Th1-driven Listeria monocytogenes was enhanced, whereas host resistance to Th2-driven Staphylococcus aureus was reduced during acute GVHD. These results suggest that opposite host responses are observed between Th1-driven and Th2-driven bacterial infections in acute GVHD.


* Corresponding author. Mailing address: Department of Bacteriology, Hirosaki University School of Medicine, Zaifu-cho 5, Hirosaki, Aomori 036-8562, Japan. Phone: 81-172-39-5032. Fax: 81-172-39-5034. E-mail: a27k03n0{at}cc.hirosaki-u.ac.jp.


Infection and Immunity, July 2000, p. 4340-4343, Vol. 68, No. 7
0019-9567/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.



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