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Infection and Immunity, July 2000, p. 4340-4343, Vol. 68, No. 7
Department of Bacteriology, Hirosaki
University School of Medicine,1 and
School of Allied Medical Sciences, Hirosaki
University,2 Hirosaki, Aomori, Japan
Received 20 January 2000/Returned for modification 1 March
2000/Accepted 12 April 2000
Acute graft-versus-host disease (GVHD) is characterized by the
production of high levels of T helper 1 (Th1)-type cytokines. Bone
marrow transplantation from allogeneic C57BL/6 cells to
CBF1 mice produced acute GVHD. Host resistance to
Th1-driven Listeria monocytogenes was enhanced, whereas
host resistance to Th2-driven Staphylococcus aureus was
reduced during acute GVHD. These results suggest that opposite host
responses are observed between Th1-driven and Th2-driven bacterial
infections in acute GVHD.
0019-9567/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.
Host Resistance to Listeria monocytogenes Infection Is
Enhanced but Resistance to Staphylococcus aureus Infection
Is Reduced in Acute Graft-versus-Host Disease in Mice
*
Corresponding author. Mailing address: Department of
Bacteriology, Hirosaki University School of Medicine, Zaifu-cho 5, Hirosaki, Aomori 036-8562, Japan. Phone: 81-172-39-5032. Fax:
81-172-39-5034. E-mail:
a27k03n0{at}cc.hirosaki-u.ac.jp.
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