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Infection and Immunity, July 2000, p. 4361-4362, Vol. 68, No. 7
0019-9567/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Granulocytic Ehrlichiosis in Mice Deficient in Phagocyte Oxidase or Inducible Nitric Oxide Synthase

Rila Banerjee, Juan Anguita, and Erol Fikrig*

Section of Rheumatology, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06520

Received 22 February 2000/Returned for modification 24 March 2000/Accepted 28 March 2000

Mice deficient in phox (gp91phox-/-) or NOS2 (NOS2-/-) were infected with the agent of human granulocytic ehrlichiosis (HGE) to evaluate the importance of these pathways in the eradication of HGE bacteria. NOS2-/- mice had delayed clearance of the HGE agent in comparison to control or gp91phox-/- mice, suggesting that reactive nitrogen intermediates play a role in the early control of HGE.

* Corresponding author. Mailing address: 608 Laboratory of Clinical Investigation, Section of Rheumatology, Department of Internal Medicine, Yale University School of Medicine, 333 Cedar St., P.O. Box 208031, New Haven, CT 06520-8031. Phone: (203) 785-2453. Fax: (203) 785-7053. E-mail: erol.fikrig{at}yale.edu.

Infection and Immunity, July 2000, p. 4361-4362, Vol. 68, No. 7
0019-9567/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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