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Infection and Immunity, July 2000, p. 4368-4369, Vol. 68, No. 7
0019-9567/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Expression of AniA, the Major Anaerobically Induced Outer Membrane Protein of Neisseria gonorrhoeae, Provides Protection against Killing by Normal Human Sera

J. A. Cardinaledagger and V. L. Clark*

Department of Microbiology and Immunology, University of Rochester, Rochester, New York 14642

Received 16 February 2000/Returned for modification 24 March 2000/Accepted 24 April 2000

Anaerobically grown Neisseria gonorrhoeae has previously been shown to have elevated serum resistance in the absence of exogenous CMP-N-acetylneuraminic acid or detectable sialylation. We hypothesized that the anaerobically induced gonococcal outer membrane protein AniA might have a role in this phenomenon, as it is the only known gonococcal protein that is absent under aerobic conditions. An N. gonorrhoeae F62 derivative, RUG7035, in which aniA is under control of the tac promoter, was used to examine the effect of AniA expression on serum resistance. In this study, we found that expression of AniA enhanced the serum resistance of N. gonorrhoeae and may account for these earlier observations.

* Corresponding author. Mailing address: University of Rochester, School of Medicine and Dentistry, Department of Microbiology and Immunology, Box 672, 601 Elmwood Ave., Rochester, NY 14642. Phone: (716) 275-3154. Fax: (716) 473-9573. E-mail: Ginny_Clark{at}urmc.rochester.edu.

dagger Present address: Department of Biological Sciences, University of Wisconsin---Milwaukee, Milwaukee, WI 53201.

Infection and Immunity, July 2000, p. 4368-4369, Vol. 68, No. 7
0019-9567/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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