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 Previous Article

Infection and Immunity, July 2000, p. 4370-4373, Vol. 68, No. 7
0019-9567/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Long-Term Immunological Memory Induced by Recombinant Oral Salmonella Vaccine Vectors

James J. Kohler, Latha Pathangey, Adnan Hasona, Ann Progulske-Fox, and Thomas A. Brown*

Department of Oral Biology, University of Florida, Gainesville, Florida 32610

Received 8 November 1999/Returned for modification 25 February 2000/Accepted 24 April 2000

We have previously shown that Salmonella enterica serovar Typhimurium expressing the hagB hemagglutinin gene from Porphyromonas gingivalis can induce primary and recall immune responses in serum and secretions in mice; however, the longevity of memory induced by oral Salmonella carriers has not been adequately demonstrated. In this study, we examined the capacity of mice to mount a recall response 52 weeks after primary immunization. Recall responses were seen in serum immunoglobulin G (IgG) and IgA following boosting at week 52, and in most cases, they were equal to or greater than the primary responses. Significant mucosal IgA recall responses in saliva and vaginal wash were also detected following boosting at week 52. In addition, there was a considerable residual response in secretions at week 51, prior to boosting. These results indicate that oral Salmonella vectors can induce long-term memory to recombinant HagB and are particularly effective at inducing long-lasting mucosal responses as well as at inducing the capacity for mucosal recall responses.

* Corresponding author. Mailing address: Department of Oral Biology, University of Florida, P.O. Box 100424, Gainesville, FL 32610. Phone: (352) 846-0780. Fax: (352) 392-7357. E-mail: tbrown{at}ufl.edu.

Infection and Immunity, July 2000, p. 4370-4373, Vol. 68, No. 7
0019-9567/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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