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Infection and Immunity, August 2000, p. 4666-4672, Vol. 68, No. 8
0019-9567/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Interleukin-10 Has Different Effects on Proliferation of Listeria monocytogenes in Livers and Spleens of Mice

Janneke N. Samsom,1,* Akke Annema,1 Minke F. Geertsma,1 Jan A. M. Langermans,1 Paul H. P. Groeneveld,1 Emile de Heer,2 and Ralph van Furth1

Department of Infectious Diseases1 and Department of Pathology,2 Leiden University Medical Center, Leiden, The Netherlands

Received 3 November 1999/Returned for modification 28 January 2000/Accepted 2 May 2000

The aim of this study was to investigate the effect of interleukin-10 (IL-10) on the course of Listeria monocytogenes infection in naive and immune mice. Treatment with IL-10 during the course of a primary infection significantly decreased the number of bacteria in the spleen and did not affect the number in the liver. During a secondary infection in immune mice treated with IL-10, the number of bacteria was significantly lower in the spleen but significantly higher in the liver in comparison to mock-treated immune mice. IL-10 treatment during a primary Listeria infection decreased the concentration of gamma interferon (IFN-gamma ) in plasma and the toxoplasmastatic activity of macrophages, whereas it increased the percentage of mildly CD3-positive T cells in the spleen. During a secondary infection, the concentration of IFN-gamma in plasma was decreased on day 1 but remained unaffected during later days of infection. From these results, we conclude that IL-10 has different effects on the proliferation of L. monocytogenes in the spleen and liver during primary and secondary Listeria infections.

* Corresponding author. Present address: Free University, Department of Cell Biology, Van der Boechorststraat 7, 1081 BT Amsterdam, The Netherlands. Phone: 31.20.444 8077. Fax: 31.20.444 8080. E-mail: jn.samsom.cell{at}med.vu.nl.

Infection and Immunity, August 2000, p. 4666-4672, Vol. 68, No. 8
0019-9567/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.




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