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Infection and Immunity, August 2000, p. 4759-4764, Vol. 68, No. 8
Department of Microbiology, University of
Texas Southwestern Medical Center, Dallas, Texas
752351; Oklahoma State University,
Stillwater, Oklahoma 740782; and Center
for Microbial Pathogenesis3 and
Department of Medicine,4 University of
Connecticut Health Center, Farmington, Connecticut 06030
Received 23 March 2000/Returned for modification 2 May
2000/Accepted 13 May 2000
Previous studies showed that decorin-binding protein A (DbpA) of
Borrelia burgdorferi was a protective immunogen in the
murine model of Lyme borreliosis when mice were challenged (needle
inoculated) intradermally with in vitro-cultivated spirochetes. In the
present study, DbpA-immunized C3H/HeJ mice were not protected from
infection when infested with Ixodes scapularis nymphs
harboring virulent B. burgdorferi 297. This lack of
protection correlated with the failure to detect DbpA on B. burgdorferi in ticks, suggesting that DbpA is not available as a
target for bactericidal antibodies in serum when B. burgdorferi-infected ticks take their blood meal from an
immunized host. The failure of DbpA immunization to protect tick-challenged mice contradicts the results of earlier needle inoculation vaccination experiments and suggests that DbpA may not be
suitable as a Lyme disease vaccine.
0019-9567/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.
Decorin-Binding Protein A (DbpA) of Borrelia
burgdorferi Is Not Protective When Immunized Mice Are Challenged
via Tick Infestation and Correlates with the Lack of DbpA
Expression by B. burgdorferi in Ticks
*
Corresponding author. Mailing address: Department of
Microbiology, University of Texas Southwestern Medical Center, 6000 Harry Hines Blvd., Dallas, TX 75235-9048. Phone: (214) 648-5900. Fax: (214) 648-5905. E-mail: norgard{at}utsw.swmed.edu.
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