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Infection and Immunity, August 2000, p. 4765-4768, Vol. 68, No. 8
0019-9567/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Chlamydia pneumoniae Induces Inflammatory Changes in the Heart and Aorta of Normocholesterolemic C57BL/6J Mice

Erwin Blessing,1 Tsun-Mei Lin,1,2 Lee Ann Campbell,1 Michael E. Rosenfeld,1,3 Deborah Lloyd,1 and Cho-chou Kuo1,*

Departments of Pathobiology1 and Interdisciplinary Graduate Program in Nutritional Sciences,3 University of Washington, Seattle, Washington 98195, and Department of Medical Technology, Medical College, National Cheng Kung University, Tainan, Taiwan 701012

Received 3 April 2000/Returned for modification 2 May 2000/Accepted 15 May 2000

Chlamydia pneumoniae infection induces inflammatory changes in blood vessels in normocholesterolemic rabbits, but it is not known whether the same phenomenon occurs in other animal models. Thus, in this study, C57BL/6J mice were inoculated with C. pneumoniae. Inflammatory changes in the heart or aorta were observed in a small number of chronically infected mice. No evidence of atherosclerotic lesions was found in any of the mice. These findings suggest that chronic C. pneumoniae infection can induce inflammatory changes in the heart and aorta of C57BL/6J mice, but does not initiate definitive atherosclerosis.

* Corresponding author. Mailing address: Department of Pathobiology, Box 357238, University of Washington, Seattle, WA 98195. Phone: (206) 543-8689. Fax: (206) 543-3873. E-mail: cckuo{at}u.washington.edu.

Infection and Immunity, August 2000, p. 4765-4768, Vol. 68, No. 8
0019-9567/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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