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Infection and Immunity, August 2000, p. 4786-4788, Vol. 68, No. 8
0019-9567/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Nonimmune Interaction of the SfbI Protein of Streptococcus pyogenes with the Immunoglobulin G F(ab')2 Fragment

Eva Medina, Kai Schulze, Gursharan Singh Chhatwal, and Carlos Alberto Guzmán*

Department of Microbial Pathogenesis and Vaccine Research, Division of Microbiology, GBF-German Research Centre for Biotechnology, D-38124 Braunschweig, Germany

Received 28 February 2000/Returned for modification 19 April 2000/Accepted 10 May 2000

Fibronectin-binding protein I (SfbI) of Streptococcus pyogenes binds to mouse immunoglobulin G (IgG) but not to IgA or IgM in a nonimmune fashion. The fibronectin-binding domains of SfbI were responsible for this activity, which was targeted to the IgG F(ab')2 fragment. SfbI also binds to B cells but not to CD4+ or CD8+ lymphocytes.

* Corresponding author. Mailing address: Department of Microbial Pathogenesis and Vaccine Research, Division of Microbiology, GBF-German Research Centre for Biotechnology, Mascheroder Weg 1, D-38124 Braunschweig, Germany. Phone: 49-531-6181558. Fax: 49-531-6181411. E-mail: cag{at}gbf.de.

Infection and Immunity, August 2000, p. 4786-4788, Vol. 68, No. 8
0019-9567/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.




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