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Infection and Immunity, August 2000, p. 4789-4791, Vol. 68, No. 8
0019-9567/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Critical Role of Neutrophils in Eliminating Listeria monocytogenes from the Central Nervous System during Experimental Murine Listeriosis

Santiago López,1 Alberto Jesús Marco,1,* Neus Prats,1 and Charles J. Czuprynski2

Department of Pathology and Animal Productions, Veterinary School, Autonomous University of Barcelona, Barcelona, Spain,1 and Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin---Madison, Madison, Wisconsin 537062

Received 10 December 1999/Returned for modification 10 February 2000/Accepted 3 May 2000

Neutrophils are the main inflammatory cell present in lesions involving the central nervous system (CNS) during human and murine listeriosis. In this study, administration of the neutrophil-depleting monoclonal antibody RB6-8C5 during experimental murine listeriosis facilitated the multiplication of Listeria monocytogenes in the CNS. These data suggest that neutrophils play a key role in eliminating bacteria that gain access to the CNS compartment. In addition, we provide evidence that their migration into the CNS may be necessary for the subsequent recruitment of macrophages and activated lymphocytes.

* Corresponding author. Mailing address: Histologia i Anatomia Patològica, Departament de Patologia i Produccions Animals, Facultat de Veterinària, Universitat Autònoma de Barcelona, 08193 Bellaterra, Barcelona, Spain. Phone: 34-3-5811420. Fax: 34-3-5813142. E-mail: Alberto.Marco{at}cc.uab.es.

Infection and Immunity, August 2000, p. 4789-4791, Vol. 68, No. 8
0019-9567/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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