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Infection and Immunity, August 2000, p. 4792-4794, Vol. 68, No. 8
0019-9567/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Streptococcus pneumoniae Induces Secretion of Vascular Endothelial Growth Factor by Human Neutrophils

Michiel van der Flier,1,2 Frank Coenjaerts,2,3 Jan L. L. Kimpen,1 Andy M. Hoepelman,2,3 and Sibyl P. M. Geelen1,*

Wilhelmina Children's Hospital,1 Eijkman-Winkler Institute for Microbiology,2 and Division of Infectious Diseases and AIDS, Department of Internal Medicine,3 University Medical Center, Utrecht, The Netherlands

Received 23 December 1999/Returned for modification 28 March 2000/Accepted 28 April 2000

Infection by pneumococci causes an acute inflammatory response associated with neutrophil influx, increased vascular permeability, and edema. Vascular endothelial growth factor (VEGF) is one of the most potent regulators of endothelial permeability. In vitro stimulation of neutrophils showed that pneumococci and purified pneumococcal cell wall induce VEGF secretion, independent of the presence of pneumolysin or polysaccharide capsule. The results of this study indicate VEGF is secreted in pneumococcal disease, suggesting a role as a mediator of increased vascular permeability.

* Corresponding author. Mailing address: UMC/Wilhelmina Children's Hospital, HP KE 04.1331, P.O. Box 85090, 3508 AB Utrecht, The Netherlands. Phone: 31 (0)30 250 4561. Fax: 31 (0)30 250 5349. E-mail: s.geelen{at}wkz.azu.nl.

Infection and Immunity, August 2000, p. 4792-4794, Vol. 68, No. 8
0019-9567/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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