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Infection and Immunity, August 2000, p. 4802-4804, Vol. 68, No. 8
0019-9567/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Dominant Nonresponsiveness to Helicobacter pylori Infection Is Associated with Production of Interleukin 10 but Not Gamma Interferon

Philip Sutton,* Tassia Kolesnikow, Stephen Danon, John Wilson, and Adrian Lee

School of Microbiology and Immunology, University of New South Wales, Sydney, New South Wales 2052, Australia

Received 22 February 2000/Returned for modification 9 April 2000/Accepted 4 May 2000

Helicobacter pylori-induced gastritis is an essential precursor lesion for the development of peptic ulcers or gastric adenocarcinoma. We demonstrate that nonresponsiveness to H. pylori SS1 infection is dominantly inherited in mice. F1 hybrid crosses between a nonresponder mouse and three responder strains all possessed the nonresponder phenotype. Secretion of interleukin-10 but not gamma interferon was associated with nonresponsiveness to infection.

* Corresponding author. Mailing address: School of Microbiology and Immunology, University of New South Wales, Sydney, NSW 2052, Australia. Phone: 61-2-9385-2098. Fax: 61-2-9385-1591. E-mail: P.Sutton{at}unsw.edu.au.

Infection and Immunity, August 2000, p. 4802-4804, Vol. 68, No. 8
0019-9567/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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