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Infection and Immunity, August 2000, p. 4822-4826, Vol. 68, No. 8
0019-9567/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Differential Infectivity and Division of Toxoplasma gondii in Human Peripheral Blood Leukocytes

Jacqueline Y. Channon,1,* Rosanne M. Seguin,2,dagger and Lloyd H. Kasper2

Departments of Microbiology1 and Medicine,2 Dartmouth Medical School, Lebanon, New Hampshire 03756

Received 31 January 2000/Returned for modification 30 March 2000/Accepted 11 May 2000

When tachyzoites were incubated with human peripheral blood leukocytes in vitro, more monocytes and dendritic cells than neutrophils or lymphocytes were infected. Although tachyzoites were able to divide in each of these cell types, monocytes and dendritic cells were more permissive to rapid tachyzoite division than neutrophils or lymphocytes.

* Corresponding author. Mailing address: Department of Microbiology, 648E Borwell, DHMC, Lebanon, NH 03756. Phone: (603) 650-8786. Fax: (603) 650-6841. E-mail: Jacqueline.Channon{at}dartmouth.edu.

dagger Present address: Department of Neuroimmunology, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada H3A 2B4.

Infection and Immunity, August 2000, p. 4822-4826, Vol. 68, No. 8
0019-9567/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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