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Infection and Immunity, September 2000, p. 4893-4899, Vol. 68, No. 9
0019-9567/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Anti-HSP70 Autoantibody Formation by B-1 Cells in Toxoplasma gondii-Infected Mice

Mei Chen, Fumie Aosai, Hye-Seong Mun, Kazumi Norose, Hidekazu Hata, and Akihiko Yano*

Department of Parasitology, Chiba University School of Medicine, Chuo-ku, Chiba 260-8670, Japan

Received 6 March 2000/Returned for modification 11 April 2000/Accepted 13 June 2000

Formation of anti-Toxoplasma gondii HSP70 (TgHSP70) antibody cross-reactive to mouse HSP70 (mHSP70) was observed in the sera of BALB/c (a resistant strain) and C57BL/6 (B6; a susceptible strain) mice after peroral infection with T. gondii cysts of the Fukaya strain. The levels of anti-mHSP70 immunoglobulin G (IgG) autoantibody production in B6 mice were higher than those in BALB/c mice. The isotype and subclass of IgG of anti-TgHSP70 monoclonal antibodies cross-reactive to mHSP70 were µ and gamma 3. Anti-mHSP70 autoantibody in T. gondii-infected BALB/c and B6 mice was shown to be produced by the CD5+ subset of B cells (B-1a cells) but not by conventional B cells (B-2 cells). The epitopes recognized by anti-mHSP70 autoantibody were located primarily in the C-terminal fragment of mHSP70.

* Corresponding author. Mailing address: Department of Parasitology, Chiba University School of Medicine, 1-8-1 Inohana, Chuo-ku, Chiba 260-8670, Japan. Phone: (81)-43-226-2071. Fax: (81)-43-226-2076. E-mail: yano{at}med.m.chiba-u.ac.jp.

Infection and Immunity, September 2000, p. 4893-4899, Vol. 68, No. 9
0019-9567/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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