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Infection and Immunity, September 2000, p. 5364-5376, Vol. 68, No. 9
0019-9567/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Immunopathology of Cerebral Malaria: Morphological Evidence of Parasite Sequestration in Murine Brain Microvasculature

Jocelyn Hearn,1 Neil Rayment,1 David N. Landon,2 David R. Katz,1 and J. Brian de Souza1,*

Department of Immunology, Royal Free and University College London Medical School, Windeyer Institute of Medical Science, London W1P 6DB,1 and Department of Neuropathology, Institute of Neurology, London WC1N 3BG,2 United Kingdom

Received 13 March 2000/Returned for modification 12 May 2000/Accepted 10 June 2000

A murine model that closely resembles human cerebral malaria is presented, in which characteristic features of parasite sequestration and inflammation in the brain are clearly demonstrable. "Young" (BALB/c × C57BL/6)F1 mice infected with Plasmodium berghei (ANKA) developed typical neurological symptoms 7 to 8 days later and then died, although their parasitemias were below 20%. Older animals were less susceptible. Immunohistopathology and ultrastructure demonstrated that neurological symptoms were associated with sequestration of both parasitized erythrocytes and leukocytes and with clogging and rupture of vessels in both cerebral and cerebellar regions. Increases in tumor necrosis factor alpha and CD54 expression were also present. Similar phenomena were absent or substantially reduced in older infected but asymptomatic animals. These findings suggest that this murine model is suitable both for determining precise pathogenetic features of the cerebral form of the disease and for evaluating circumventive interventions.

* Corresponding author. Mailing address: Department of Immunology, Royal Free and University College London Medical School, Windeyer Institute of Medical Science, 46 Cleveland Street, London W1P 6DB, United Kingdom. Phone: 44-020 7679 9354. Fax: 44-020 7679 9357. E-mail: J.deSouza{at}ucl.ac.uk.

Infection and Immunity, September 2000, p. 5364-5376, Vol. 68, No. 9
0019-9567/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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