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Infection and Immunity, September 2000, p. 5405-5407, Vol. 68, No. 9
0019-9567/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Transforming Growth Factor beta 1 Is Expressed in the Jejunum after Experimental Cryptosporidium parvum Infection in Humans

Prema Robinson,1 Pablo C. Okhuysen,2,3 Cynthia L. Chappell,2,3 Dorothy E. Lewis,4 Imran Shahab,5 Sandeep Lahoti,2 and A. Clinton White Jr.1,6,*

Departments of Molecular Virology and Microbiology,1 Immunology,4 Medicine,6 and Pathology,5 Baylor College of Medicine, and Departments of Medicine2 and School of Public Health,3 University of Texas Health Sciences Center, Houston, Texas 77030

Received 13 March 2000/Returned for modification 23 April 2000/Accepted 15 May 2000

Biopsies from volunteers challenged with Cryptosporidium parvum were examined for transforming growth factor beta 1 (TGF-beta 1). None of the prechallenge biopsies exhibited TGF-beta . Seven of 12 volunteers with oocyst shedding expressed TGF-beta versus 2 of 13 volunteers without detected oocysts. The association of TGF-beta expression with oocyst excretion and the timing of symptoms suggests that TGF-beta mediates intestinal healing.

* Corresponding author. Mailing address: Infectious Diseases Section, Department of Medicine, Baylor College of Medicine, One Baylor Plaza, Room 561E, Houston, TX 77030. Phone: (713) 798-6846. Fax: (713) 790-0681. E-mail: arthurw{at}bcm.tmc.edu.

Infection and Immunity, September 2000, p. 5405-5407, Vol. 68, No. 9
0019-9567/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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