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Infection and Immunity, September 2000, p. 5412-5415, Vol. 68, No. 9
0019-9567/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Regulation of Human beta -Defensins by Gastric Epithelial Cells in Response to Infection with Helicobacter pylori or Stimulation with Interleukin-1

Deborah A. O'Neil,1 Sheri P. Cole,2 Edith Martin-Porter,3 Michael P. Housley,1 Lide Liu,3 Tomas Ganz,3 and Martin F. Kagnoff1,*

Laboratory of Mucosal Immunology, Department of Medicine, University of California, San Diego, La Jolla, California 92093-06231; Department of Medicine, University of California, San Diego, La Jolla, California 92093-06402; and Will Rogers Pulmonary Research Laboratory, Department of Medicine, University of California, Los Angeles, California 90095-17363

Received 7 April 2000/Returned for modification 2 June 2000/Accepted 15 June 2000

Gastric epithelial cells in vitro and in vivo are shown to constitutively express the peptide antibiotic human beta -defensin type 1 (hBD-1). In contrast, hBD-2 expression is regulated in gastric epithelial cells and increases in response to infection with Helicobacter pylori or stimulation with the proinflammatory cytokine interleukin-1. These data suggest that hBD-2 is a component of the regulated host gastric epithelial cell response to H. pylori infection and proinflammatory mediators.

* Corresponding author. Mailing address: Laboratory of Mucosal Immunology, Department of Medicine (0623D), University of California, San Diego, 9500 Gilman Dr., La Jolla, CA 92093-0623. Phone: (858) 534-4622. Fax: (858) 534-5691. E-mail: mkagnoff{at}ucsd.edu.

Infection and Immunity, September 2000, p. 5412-5415, Vol. 68, No. 9
0019-9567/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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