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Infection and Immunity, September 2000, p. 5425-5429, Vol. 68, No. 9
0019-9567/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Possible Release of an ArgGlyArgProGln Pentapeptide with Innate Immunity Properties from Acidic Proline-Rich Proteins by Proteolytic Activity in Commensal Streptococcus and Actinomyces Species

Tong Li,1 Per Bratt,1 Andreas P. Jonsson,2 Mats Ryberg,1 Ingegerd Johansson,1 William J. Griffiths,2 Tomas Bergman,2 and Nicklas Strömberg1,*

Department of Cariology, Umeå University, SE-901 87 Umeå,1 and Department of Medical Biochemistry and Biophysics, Karolinska Institutet, SE-171 77 Stockholm,2 Sweden

Received 14 February 2000/Returned for modification 16 March 2000/Accepted 21 May 2000

This study suggests degradation of salivary acidic proline-rich proteins (PRPs) into potential innate-immunity-like peptides by oral Streptococcus and Actinomyces species. PRP degradation paralleled cleavage of Pro-containing substrates. PRP degradation by S. gordonii strain SK12 instantly released a Pyr1-Pro104Pro105 and a Gly111-Pro149Gln150 peptide together with a presumed Arg106Gly107Arg108Pro109Gln110 pentapeptide. The synthetic Arg106Gly107Arg108Pro109Gln110 peptide desorbed bound bacteria and counteracted sucrose-induced decrease of dental plaque pH in vitro.

* Corresponding author. Mailing address: Department of Cariology, Odontology, Umeå University, SE-901 87 Umeå, Sweden. Phone: 46-90-7856030. Fax: 46-90-770580. E-mail: Nicklas.Stromberg{at}odont.umu.se.

Infection and Immunity, September 2000, p. 5425-5429, Vol. 68, No. 9
0019-9567/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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