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Infection and Immunity, September 2000, p. 5430-5434, Vol. 68, No. 9
Laboratory of Parasitology, Faculty of
Medicine, University of Brussels, Brussels,
Belgium,1 and CUMETROP/LABIMED, Faculty
of Medicine, Universidad Mayor de San Simon Cochabamba,
Bolivia2
Received 15 February 2000/Returned for modification 28 March
2000/Accepted 12 June 2000
The possibility of maternal in utero modulation of the innate
and/or adaptive immune responses of uninfected newborns from Trypanosoma cruzi-infected mothers was investigated by
studying the capacity of their whole blood cells to produce cytokines
in response to T. cruzi lysate or
lipopolysaccharide-plus-phytohemagglutinin (LPS-PHA) stimulation. Cells
of such newborns occasionally released gamma interferon (IFN-
0019-9567/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.
Maternal Trypanosoma cruzi Infection
Upregulates Capacity of Uninfected Neonate Cells To Produce Pro- and
Anti-Inflammatory Cytokines
) and
no interleukin-2 (IL-2) and IL-4 upon specific stimulation, while their
mothers responded by the production of IFN-, IL-2, and IL-4.
Infection in mothers was also associated with a hyperactivation of
maternal cells and also, strikingly, of cells of their uninfected
neonates, since their release of proinflammatory (IL-1
, IL-6, and
tumor necrosis factor alpha [TNF-
]) as well as of
anti-inflammatory (IL-10 and soluble TNF receptor) cytokines or factors
was upregulated in the presence of LPS-PHA and/or parasite lysate.
These results show that T. cruzi infection in mothers
induces profound perturbations in the cytokine response of their
uninfected neonates. Such maternal influence on neonatal innate
immunity might contribute to limit the occurrence and severity of
congenital infection.
*
Corresponding author. Mailing address: Laboratoire de
Parasitologie, Faculté de Médecine U.L.B., route de Lennik
808, CP 616, B-1070 Brussels, Belgium. Phone: 32 2 555 62 50. Fax: 32 2 555 61 28. E-mail: ycarlier{at}ulb.ac.be.
Present address: Medical Research Council, Fajara, The Gambia.
Infection and Immunity, September 2000, p. 5430-5434, Vol. 68, No. 9
0019-9567/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.
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