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Infection and Immunity, September 2000, p. 5435-5438, Vol. 68, No. 9
0019-9567/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Clminus Secretion in Colonic Epithelial Cells Induced by the Vibrio parahaemolyticus Hemolytic Toxin Related to Thermostable Direct Hemolysin

Akira Takahashi,1,2,* Noriko Kenjyo,1 Kinichi Imura,1 Yoh Myonsun,2 and Takeshi Honda1

Department of Bacterial Infections, Research Institute for Microbial Diseases, Osaka University, 3-1, Yamadaoka, Suita, Osaka 565-0871,1 and Department of Nutrition, School of Medicine, Tokushima University, Tokushima City, 770-8503,2 Japan

Received 22 February 2000/Returned for modification 17 April 2000/Accepted 13 June 2000

A hemolytic toxin related to thermostable direct hemolysin (TDH), TDH-related hemolysin (TRH), produced by Kanagawa-phenomenon-negative Vibrio parahaemolyticus is suspected of playing an important, but yet-to-be-elucidated role in diarrhea caused by this organism. In cultured human colonic epithelial cells, TRH increases Cl- secretion, followed by elevation of intracellular calcium.

* Corresponding author. Mailing address: Department of Nutrition, School of Medicine, Tokushima University, 3-18-15 Kuramoto-cho, Tokushima City, 770-8503, Japan. Phone: 81-6-6879-8276. Fax: 81-6-6879-8277. E-mail: akiratak{at}biken.osaka-u.ac.jp.

Infection and Immunity, September 2000, p. 5435-5438, Vol. 68, No. 9
0019-9567/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:

  • Berkes, J, Viswanathan, V K, Savkovic, S D, Hecht, G (2003). Intestinal epithelial responses to enteric pathogens: effects on the tight junction barrier, ion transport, and inflammation. Gut 52: 439-451 [Abstract] [Full Text]  


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