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Infection and Immunity, September 2000, p. 5447-5449, Vol. 68, No. 9
0019-9567/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Direct Evidence for Involvement of NF-kappa B in Transcriptional Activation of Tumor Necrosis Factor by a Spirochetal Lipoprotein

Irina A. Udalova,* Vincent Vidal, Ian G. Scragg, and Dominic Kwiatkowski

Molecular Infectious Disease Group, Institute of Molecular Medicine, The John Radcliffe Hospital, Oxford OX3 9DS, United Kingdom

Received 29 November 1999/Returned for modification 23 February 2000/Accepted 9 June 2000

Variable major lipoprotein (Vmp) is a major tumor necrosis factor (TNF)-inducing component of Borrelia recurrentis, the agent of louse-borne relapsing fever. B. recurrentis Vmp rapidly stimulates nuclear translocation of NF-kappa B and proinflammatory cytokine gene expression in the human monocyte-like cell line MonoMac 6. By overexpressing disabled mutant Ikappa Balpha in MonoMac 6 cells cotransfected with a reporter gene, we provide evidence that NF-kappa B is essential for the transcriptional activation of TNF in this system.

* Corresponding author. Mailing address: Molecular Infectious Disease Group, Institute of Molecular Medicine, The John Radcliffe Hospital, Oxford OX3 9DS, United Kingdom. Phone: 44 1865 222345. Fax: 44 1865 222626. E-mail: iudalova{at}molbiol.ox.ac.uk.

Infection and Immunity, September 2000, p. 5447-5449, Vol. 68, No. 9
0019-9567/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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