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Infection and Immunity, September 2000, p. 5462-5465, Vol. 68, No. 9
0019-9567/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Role of Inducible Nitric Oxide Synthase in Resistance to Mycobacterium leprae in Mice

Linda B. Adams,1,* Charles K. Job,2 and James L. Krahenbuhl1

National Hansen's Disease Programs, Laboratory Research Branch at Louisiana State University, Baton Rouge, Louisiana,1 and St. Thomas Hospital and Leprosy Centre, Chettupattu TS Dt 606 801 Tamil Nadu, South India2

Received 2 December 1999/Returned for modification 14 February 2000/Accepted 5 June 2000

The manifestation of leprosy in humans is largely determined by host immunity to Mycobacterium leprae and is a model for immunoregulation in a human disease. However, animal models available for exploration of the leprosy spectrum are inadequate. This study explored M. leprae infection in mice deficient in inducible nitric oxide synthase, and this report describes elements resembling borderline tuberculoid leprosy in humans.

* Corresponding author. Mailing address: National Hansen's Disease Programs, Laboratory Research Branch at Louisiana State University, P.O. Box 25072, Baton Rouge, LA 70894. Phone: (225) 346-5764. Fax: (225) 346-5786. E-mail: ladams1{at}lsu.edu.

Infection and Immunity, September 2000, p. 5462-5465, Vol. 68, No. 9
0019-9567/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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