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Infection and Immunity, January 2001, p. 426-434, Vol. 69, No. 1
0019-9567/01/$04.00+0   DOI: 10.1128/IAI.69.1.426-434.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Role of Genetic Resistance in Invasive Pneumococcal Infection: Identification and Study of Susceptibility and Resistance in Inbred Mouse Strains

Neill A. Gingles,1 Janet E. Alexander,1 Aras Kadioglu,1 Peter W. Andrew,1,* Alison Kerr,2 Timothy J. Mitchell,2 Elaine Hopes,3 Paul Denny,3 Steve Brown,3 Huw B. Jones,4 Steve Little,4 George C. Booth,4 and William L. McPheat4

Department of Microbiology and Immunology, University of Leicester,1 Division of Infection and Immunity, University of Glasgow,2 MRC Mouse Genome Centre, Harwell,3 and AstraZeneca plc, Alderley Edge,4 United Kingdom

Received 5 April 2000/Returned for modification 10 July 2000/Accepted 13 October 2000

From a panel of nine inbred mice strains intranasally infected with Streptococcus pneumoniae type 2 strain, BALB/c mice were resistant and CBA/Ca and SJL mice were susceptible to infection. Further investigation revealed that BALB/c mice were able to prevent proliferation of pneumococci in the lungs and blood, whereas CBA/Ca mice showed no bacterial clearance. Rapidly increasing numbers of bacteria in the blood was a feature of CBA/Ca but not BALB/c mice. In the lungs, BALB/c mice recruited significantly more neutrophils than CBA/Ca mice at 12 and 24 h postinfection. Inflammatory lesions in BALB/c mice were visible much earlier than in CBA/Ca mice, and there was a greater cellular infiltration into the lung tissue of BALB/c mice at the earlier time points. Our data suggest that resistance or susceptibility to intranasal pneumococci may have an association with recruitment and/or function of neutrophils.

* Corresponding author. Mailing address: Department of Microbiology and Immunology, P.O. Box 138, Medical Sciences Building, University Rd., Leicester LE1 9HN, United Kingdom. Phone: 44 116 2523018. Fax: 44 116 2525030. E-mail: PWA{at}LE.AC.UK.

Infection and Immunity, January 2001, p. 426-434, Vol. 69, No. 1
0019-9567/01/$04.00+0   DOI: 10.1128/IAI.69.1.426-434.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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