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Infection and Immunity, January 2001, p. 551-555, Vol. 69, No. 1
0019-9567/01/$04.00+0   DOI: 10.1128/IAI.69.1.551-555.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Severity of Group B Streptococcal Arthritis in Selected Strains of Laboratory Mice

Manuela Puliti,1 Francesco Bistoni,1 Christina von Hunolstein,2 Graziella Orefici,2 and Luciana Tissi1,*

Microbiology Section, Department of Experimental Medicine and Biochemical Sciences, University of Perugia, 06122 Perugia,1 and Laboratory of Bacteriology and Medical Micology, Istituto Superiore di Sanità, Rome,2 Italy

Received 24 July 2000/Returned for modification 19 September 2000/Accepted 5 October 2000

The susceptibilities of C3H/HeN, BALB/c, and C57BL/6N mouse strains to group B streptococci (GBS) infection were evaluated. C3H/HeN mice developed severe polyarthitis; mild lesions and no lesions were observed in BALB/c and C57BL/6N mice, respectively. A correlation between the severity of arthritis, the number of GBS in the joints, and local interleukin-6 and interleukin-1beta production was evident.


* Corresponding author. Mailing address: Microbiology Section, Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Via del Giochetto, 06122 Perugia, Italy. Phone: 39-075-585-7409. Fax: 39-075-585-7403. E-mail: tissi{at}unipg.it.


Infection and Immunity, January 2001, p. 551-555, Vol. 69, No. 1
0019-9567/01/$04.00+0   DOI: 10.1128/IAI.69.1.551-555.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.



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Copyright © 2001 by the American Society for Microbiology. All rights reserved.