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Infection and Immunity, January 2001, p. 556-558, Vol. 69, No. 1
0019-9567/01/$04.00+0   DOI: 10.1128/IAI.69.1.556-558.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Immunity against Helicobacter pylori: Significance of Interleukin-4 Receptor alpha  Chain Status and Gender of Infected Mice

Toni Aebischer,1,* Stephanie Laforsch,1 Robert Hurwitz,1 Frank Brombacher,2 and Thomas F. Meyer1

Department of Molecular Biology, Max Planck Institute for Infection Biology, 10117 Berlin, Germany,1 and Infectious Disease Unit, Faculty of Health Science, Groote Schuur Hospital, University of Cape Town, Cape Town, South Africa2

Received 3 July 2000/Returned for modification 18 September 2000/Accepted 9 October 2000

Vaccination of interleukin-4 (IL-4) receptor alpha  (IL-4Ralpha ) chain-deficient BALB/c mice with Helicobacter pylori urease and cholera toxin or with urease-expressing, live attenuated Salmonella enterica serovar Typhimurium cells revealed that protection against H. pylori infection is independent of IL-4- or IL-13-mediated signals. A comparison of male and female mice suggests a sexual dimorphism in the extent of bacterial colonization that is particularly evident in the absence of the IL-4Ralpha chain.

* Corresponding author. Mailing address: Department of Molecular Biology, Max Planck Institute for Infection Biology, Schumannstrasse 21/22, 10117 Berlin, Germany. Phone: 49 30 28460 400. Fax: 49 30 28460 401. E-mail: aebischer{at}mpiib-berlin.mpg.de.

Infection and Immunity, January 2001, p. 556-558, Vol. 69, No. 1
0019-9567/01/$04.00+0   DOI: 10.1128/IAI.69.1.556-558.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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