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Infection and Immunity, January 2001, p. 575-578, Vol. 69, No. 1
0019-9567/01/$04.00+0   DOI: 10.1128/IAI.69.1.575-578.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Tick Salivary Gland Extract Inhibits Killing of Borrelia afzelii Spirochetes by Mouse Macrophages

Marie Kuthejlová,1 Jan Kopecký,1,2,* Gabriela Stepánová,1 and Ales Macela3

Institute of Parasitology, Academy of Sciences of the Czech Republic,1 and Faculty of Biological Sciences, University of South Bohemia,2 Ceské Budejovice, and Institute for Immunology, Purkyne Military Medical Academy, Hradec Králové,3 Czech Republic

Received 23 June 2000/Returned for modification 19 August 2000/Accepted 30 September 2000

Salivary gland extract (SGE) from Ixodes ricinus ticks inhibited the killing of Borrelia afzelii spirochetes by murine macrophages. SGE also reduced the production of two major defense molecules of phagocytes, superoxide and nitric oxide. It is likely that the suppression of macrophage microbicidal mechanisms contributes to the inhibitory effect of tick saliva on the killing of B. afzelii spirochetes, thus facilitating the transmission of this important pathogen.

* Corresponding author. Mailing address: Institute of Parasitology, Academy of Sciences of the Czech Republic, Branisovská 31, 370 05 Ceské Budejovice, Czech Republic. Phone: 420 38 777 5468. Fax: 420 38 5300388. E-mail: jan{at}paru.cas.cz.

Infection and Immunity, January 2001, p. 575-578, Vol. 69, No. 1
0019-9567/01/$04.00+0   DOI: 10.1128/IAI.69.1.575-578.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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