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Infection and Immunity, January 2001, p. 593-598, Vol. 69, No. 1
0019-9567/01/$04.00+0   DOI: 10.1128/IAI.69.1.593-598.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Homologous and Heterologous Borrelia burgdorferi Challenge of Infection-Derived Immune Rabbits Using Host-Adapted Organisms

Ellen S. Shang,1,* Xiao-yang Wu,1 Michael A. Lovett,2 James N. Miller,1,* and David R. Blanco1,2

Department of Microbiology, Immunology and Molecular Genetics1 and Division of Infectious Diseases, Department of Medicine,2 University of California School of Medicine, Los Angeles, California 90095

Received 10 August 2000/Returned for modification 20 September 2000/Accepted 20 October 2000

We have recently found that strain B31 infection-immune rabbits are completely protected against homologous challenge with large numbers (>106) of host-adapted Borrelia burgdorferi (HAB) (E. S. Shang, C. I. Champion, X. Wu, J. T. Skare, D. B. Blanco, J. N. Miller, and M. A. Lovett, Infect. Immun. 68:4189-4199, 2000). In this study, we have extended these findings to determine whether B31 strain infection-immune rabbits are also protected against heterologous HAB challenge. Infection-immune rabbits challenged with large numbers (>106) of homologous HAB strain B31 were completely protected from erythema migrans (EM) and skin and disseminated infection. In contrast, infection-immune rabbits challenged with heterologous HAB strains N40 and Sh-2-82 were completely susceptible to EM and skin and disseminated infection; challenge with strain 297 also resulted in EM and infection of the skin and viscera, but clearance of infection occurred 3 weeks postchallenge. These findings confirm that immunity elicited in rabbits by B31 strain infection confers complete protection against large-dose homologous HAB challenge but not against a heterologous strain.

* Corresponding authors. Mailing address: Department of Microbiology and Immunology, UCLA School of Medicine, 10833 Le Conte Ave. CHS 43-239, Los Angeles, CA 90095. Phone: (310) 825-4188 or (310) 825-1979. Fax: (310) 267-2265. E-mail: eshang{at}mednet.ucla.edu or jmiller{at}microimmun.medsch.ucla.edu.

Infection and Immunity, January 2001, p. 593-598, Vol. 69, No. 1
0019-9567/01/$04.00+0   DOI: 10.1128/IAI.69.1.593-598.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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