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Infection and Immunity, October 2001, p. 6110-6118, Vol. 69, No. 10
0019-9567/01/$04.00+0   DOI: 10.1128/IAI.69.10.6110-6118.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

T Cells Augment Monocyte and Neutrophil Function in Host Resistance against Oropharyngeal Candidiasis

C. S. Farah,1,* S. Elahi,2 G. Pang,2 T. Gotjamanos,3 G. J. Seymour,1 R. L. Clancy,2 and R. B. Ashman1

Oral Biology and Pathology, School of Dentistry, University of Queensland, Brisbane, Queensland 4072,1 Discipline of Immunology and Microbiology, University of Newcastle, Newcastle, New South Wales 2300,2 and Department of Pathology, Queen Elizabeth II Medical Centre, University of Western Australia, Nedlands, Western Australia 6907,3 Australia

Received 25 January 2001/Returned for modification 21 March 2001/Accepted 23 July 2001

The purpose of this study was to identify the cell populations involved in recovery from oral infections with Candida albicans. Monoclonal antibodies specific for CD4+ cells, CD8+ cells, and polymorphonuclear leukocytes were used to deplete BALB/c and CBA/CaH mice of the relevant cell populations in systemic circulation. Monocytes were inactivated with the cytotoxic chemical carrageenan. Mice were infected with 108 C. albicans yeast cells and monitored for 21 days. Systemic depletion of CD4+ and CD8+ T lymphocytes alone did not increase the severity of oral infection compared to that of controls. Oral colonization persisted in animals treated with head and neck irradiation and depleted of CD4+ T cells, whereas infections in animals that received head and neck irradiation alone or irradiation and anti-CD8 antibody cleared the infection in a comparable fashion. The depletion of polymorphonuclear cells and the cytotoxic inactivation of mononuclear phagocytes significantly increased the severity of oral infection in both BALB/c and CBA/CaH mice. High levels of interleukin 12 (IL-12) and gamma interferon (IFN-gamma ) were produced by lymphocytes from the draining lymph nodes of recovering animals, whereas IL-6, tumor necrosis factor alpha, and IFN-gamma were detected in the oral mucosae of both naïve and infected mice. The results indicate that recovery from oropharyngeal candidiasis in this model is dependent on CD4+-T-cell augmentation of monocyte and neutrophil functions exerted by Th1-type cytokines such as IL-12 and IFN-gamma .

* Corresponding author. Mailing address: Oral Biology and Pathology, The University of Queensland, Brisbane, QLD 4072, Australia. Phone: 61 7 3365 8840. Fax: 61 7 3365 1109. E-mail: c.farah{at}uq.edu.au.

Infection and Immunity, October 2001, p. 6110-6118, Vol. 69, No. 10
0019-9567/01/$04.00+0   DOI: 10.1128/IAI.69.10.6110-6118.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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