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Infection and Immunity, October 2001, p. 6119-6122, Vol. 69, No. 10
0019-9567/01/$04.00+0   DOI: 10.1128/IAI.69.10.6119-6122.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Essential Role for Estrogen in Protection against Vibrio vulnificus-Induced Endotoxic Shock

Sandra M. Merkel, Sarah Alexander, Eric Zufall, James D. Oliver,* and Yvette M. Huet-Hudson

Department of Biology, University of North Carolina at Charlotte, Charlotte, North Carolina 28223

Received 30 January 2001/Returned for modification 8 May 2001/Accepted 11 July 2001

Little is known about the underlying mechanisms that result in a sexually dimorphic response to Vibrio vulnificus endotoxic shock. V. vulnificus is a gram-negative bacterium, considered one of the most invasive and rapidly fatal human pathogens known. However, 85% of individuals that develop endotoxic shock from V. vulnificus are males. Using the rat, we have developed a model for V. vulnificus endotoxic shock that mimics the sexually dimorphic response in humans. Gonadectomy in females results in increased mortality, and estrogen replacement results in decreased mortality in both gonadectomized males and females. These results demonstrate that estrogen is providing protection against V. vulnificus lipopolysaccharide-induced endotoxic shock.

* Corresponding author. Mailing address: Department of Biology, University of North Carolina at Charlotte, Charlotte, NC 28233. Phone: (704) 687-4049. Fax: (704) 687-3457. E-mail: idoliver{at}emailuncc.edu.

Infection and Immunity, October 2001, p. 6119-6122, Vol. 69, No. 10
0019-9567/01/$04.00+0   DOI: 10.1128/IAI.69.10.6119-6122.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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