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Infection and Immunity, October 2001, p. 6515-6519, Vol. 69, No. 10
0019-9567/01/$04.00+0   DOI: 10.1128/IAI.69.10.6515-6519.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Cytotoxic Necrotizing Factor Type 1-Positive Escherichia coli Causes Increased Inflammation and Tissue Damage to the Prostate in a Rat Prostatitis Model

Karen E. Rippere-Lampe,1 Michael Lang,2 Howard Ceri,2 Merle Olson,2 Hank A. Lockman,3,4 and A. D. O'Brien1,*

Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814-47991; Department of Biological Sciences, University of Calgary, Calgary, Canada2; and Children's Research Institute, Children's Hospital,3 and Division of Molecular Medicine, Department of Pediatrics, College of Medicine and Public Health, The Ohio State University,4 Columbus, Ohio 43205-2696

Received 26 April 2001/Returned for modification 18 June 2001/Accepted 11 July 2001

Infection of rat prostates with cytotoxic necrotizing factor type 1 (CNF1)-positive uropathogenic Escherichia coli caused more inflammation-mediated morphological and histological tissue damage than did infection with isogenic CNF1-negative mutants. These striking differences occurred despite the finding that bacterial counts for the strain pairs were indistinguishable. We conclude that CNF1 contributes to E. coli virulence in a model of acute prostatitis. To our knowledge, the results of this study provide the first demonstration of a role for any uropathogenic E. coli virulence factor in acute prostatitis.

* Corresponding author. Mailing address: Department of Microbiology and Immunology, USUHS, 4301 Jones Bridge Rd., Bethesda, MD 20814. Phone: (301) 295-3419. Fax: (301) 295-3773. E-mail: aobrien{at}usuhs.mil.

Infection and Immunity, October 2001, p. 6515-6519, Vol. 69, No. 10
0019-9567/01/$04.00+0   DOI: 10.1128/IAI.69.10.6515-6519.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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