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Infection and Immunity, October 2001, p. 6515-6519, Vol. 69, No. 10
Department of Microbiology and Immunology, Uniformed
Services University of the Health Sciences, Bethesda, Maryland
20814-47991; Department of Biological
Sciences, University of Calgary, Calgary,
Canada2; and Children's Research
Institute, Children's Hospital,3 and
Division of Molecular Medicine, Department of Pediatrics,
College of Medicine and Public Health, The Ohio State
University,4 Columbus, Ohio 43205-2696
Received 26 April 2001/Returned for modification 18 June
2001/Accepted 11 July 2001
Infection of rat prostates with cytotoxic necrotizing factor type 1 (CNF1)-positive uropathogenic Escherichia coli caused more inflammation-mediated morphological and histological tissue damage
than did infection with isogenic CNF1-negative mutants. These striking
differences occurred despite the finding that bacterial counts for the
strain pairs were indistinguishable. We conclude that CNF1 contributes
to E. coli virulence in a model of acute prostatitis. To our knowledge, the results of this study provide the
first demonstration of a role for any uropathogenic E.
coli virulence factor in acute prostatitis.
0019-9567/01/$04.00+0 DOI: 10.1128/IAI.69.10.6515-6519.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.
Cytotoxic Necrotizing Factor Type 1-Positive Escherichia
coli Causes Increased Inflammation and Tissue Damage to the
Prostate in a Rat Prostatitis Model
*
Corresponding author. Mailing address: Department of
Microbiology and Immunology, USUHS, 4301 Jones Bridge Rd., Bethesda, MD 20814. Phone: (301) 295-3419. Fax: (301) 295-3773. E-mail: aobrien{at}usuhs.mil.
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