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Infection and Immunity, October 2001, p. 6523-6526, Vol. 69, No. 10
0019-9567/01/$04.00+0   DOI: 10.1128/IAI.69.10.6523-6526.2001

New Zealand White Rabbit as a Nonsurgical Experimental Model for Salmonella enterica Gastroenteritis

D. E. Hanes,1,* M. G. Robl,1 C. M. Schneider,2 and D. H. Burr1

U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, Laurel, Maryland,1 and Temple University, Philadelphia, Pennsylvania2

Received 13 February 2001/Returned for modification 3 April 2001/Accepted 4 July 2001

Rabbits orally challenged with Salmonella enterica developed a dose-dependent diarrheal disease comparable to human salmonellosis. Viable Salmonella organisms recovered from the intestine and deep tissues indicate local and systemic infections. Therefore, results show that the rabbit can be used as a model for diarrheal disease and sequelae associated with salmonellosis.

* Corresponding author. Mailing address: Food and Drug Administration, 8301 Muirkirk Rd., Laurel, MD 20708. Phone and fax: (301) 827-8079. E-mail: Dhanes{at}cfsan.fda.gov.

Infection and Immunity, October 2001, p. 6523-6526, Vol. 69, No. 10
0019-9567/01/$04.00+0   DOI: 10.1128/IAI.69.10.6523-6526.2001


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