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Infection and Immunity, October 2001, p. 6541-6544, Vol. 69, No. 10
0019-9567/01/$04.00+0   DOI: 10.1128/IAI.69.10.6541-6544.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Mouse Cytokine Profiles Associated with Brucella abortus RB51 Vaccination or B. abortus 2308 Infection

Paolo Pasquali,1,* Rosanna Adone,1 Louis C. Gasbarre,2 Claudia Pistoia,1 and Franco Ciuchini1

Laboratory of Veterinary Medicine, Istituto Superiore di Sanità, 00161 Rome, Italy,1 and Immunology and Disease Resistance Laboratory, Animal and Natural Resources Institute, Agricultural Research Service, United States Department of Agriculture, Beltsville, Maryland 207052

Received 27 February 2001/Returned for modification 18 April 2001/Accepted 25 July 2001

This study indicated that mice immunized with Brucella abortus RB51 bacteria and subsequently challenged with B. abortus 2308 were protected from reinfection. After vaccination, both Th1 and Th2 cytokine patterns were observed. Of those, the early production of gamma interferon seems to have the prominent role in inducing an immunologically based protection.

* Corresponding author. Mailing address: Laboratory of Veterinary Medicine, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Rome, Italy. Phone: 39 (0)6 49902728. Fax: 39 (0)6 49387077. E-mail: pasquali{at}iss.it.

Infection and Immunity, October 2001, p. 6541-6544, Vol. 69, No. 10
0019-9567/01/$04.00+0   DOI: 10.1128/IAI.69.10.6541-6544.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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