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Infection and Immunity, October 2001, p. 6554-6557, Vol. 69, No. 10
0019-9567/01/$04.00+0   DOI: 10.1128/IAI.69.10.6554-6557.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Tuberculosis Contacts but Not Patients Have Higher Gamma Interferon Responses to ESAT-6 than Do Community Controls in The Gambia

Johan Vekemans,1,2,* Christian Lienhardt,1,3 Jackson S. Sillah,1,4 Jeremy G. Wheeler,3 George P. Lahai,1 Mark T. Doherty,5 Tumani Corrah,1 Peter Andersen,5 Keith P. W. J. McAdam,1 and Arnaud Marchant1

Medical Research Council Laboratories, Fajara,1 and National Tuberculosis Control Programme, Banjul,4 The Gambia; Université Libre de Bruxelles, Brussels, Belgium2; London School of Hygiene and Tropical Medicine, London, United Kingdom3; and Statens Serum Institut, Copenhagen, Denmark5

Received 8 December 2000/Returned for modification 22 January 2001/Accepted 9 July 2001

The Mycobacterium tuberculosis antigen ESAT-6 has been proposed for tuberculosis immunodiagnosis. In The Gambia, 30% of community controls produced gamma interferon (IFN-gamma ) in response to ESAT-6. Increased proportions of responders and intensities of responses were found in household contacts. Responses that were initially low in tuberculosis patients increased after treatment. An ESAT-6 IFN-gamma assay will be of limited use in the diagnosis of tuberculosis in countries where tuberculosis is endemic. Its role in contact tracing should be evaluated further.

* Corresponding author. Mailing address: Laboratoire d'Immunologie Expérimentale, Bâtiment GE, Faculté de Médecine, 808 Route de Lennik, 1070 Brussels, Belgium. Phone: 220 495 442. Fax: 32 2 675 7878. E-mail: Johan.Vekemans{at}ulb.ac.be.

Infection and Immunity, October 2001, p. 6554-6557, Vol. 69, No. 10
0019-9567/01/$04.00+0   DOI: 10.1128/IAI.69.10.6554-6557.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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