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Infection and Immunity, November 2001, p. 7162-7164, Vol. 69, No. 11
0019-9567/01/$04.00+0   DOI: 10.1128/IAI.69.11.7162-7164.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Resistance of T-Cell Receptor delta -Chain-Deficient Mice to Experimental Candida albicans Vaginitis

Floyd L. Wormley Jr.,1 Chad Steele,1 Karen Wozniak,1 Kohtaro Fujihashi,2 Jerry R. McGhee,2 and Paul L. Fidel Jr.1,*

Department of Microbiology, Immunology, and Parasitology, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112,1 and Immunobiology Vaccine Center, Medical Center, The University of Alabama at Birmingham, Birmingham, Alabama 352942

Received 28 March 2001/Returned for modification 10 May 2001/Accepted 8 August 2001

Conditions consistent with tolerance or immunoregulation have been observed in experimental Candida albicans vaginal infections. The present study investigated the role of gamma /delta T cells in experimental vaginal candidiasis. Results showed that T-cell receptor delta -chain-knockout mice had significantly less vaginal fungal burden when compared to wild-type mice, suggesting an immunoregulatory role for gamma /delta T cells in Candida vaginitis.

* Corresponding author. Mailing address: Department of Microbiology, Immunology, and Parasitology, Louisiana State University Health Sciences Center, 1901 Perdido St., New Orleans, LA 70112-1393. Phone: (504) 568-4066. Fax: (504) 568-4066. E-mail: pfidel{at}lsuhsc.edu.

Infection and Immunity, November 2001, p. 7162-7164, Vol. 69, No. 11
0019-9567/01/$04.00+0   DOI: 10.1128/IAI.69.11.7162-7164.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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Copyright © 2001 by the American Society for Microbiology. All rights reserved.