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Infection and Immunity, November 2001, p. 7173-7177, Vol. 69, No. 11
0019-9567/01/$04.00+0   DOI: 10.1128/IAI.69.11.7173-7177.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

A 4.1-Kilodalton Polypeptide in the Cultural Supernatant of Mycoplasma fermentans Is One of the Substances Responsible for Induction of Interleukin-6 Production by Human Gingival Fibroblasts

Akira Hasebe,* Ken-Ichiro Shibata, and Tsuguo Watanabe

Department of Oral Pathobiological Science, Graduate School of Dental Medicine, Hokkaido University, Nishi 7, Kita 13, Kita-ku, Sapporo 060-8586, Japan

Received 3 April 2001/Returned for modification 20 June 2001/Accepted 20 August 2001

The cultural supernatant of Mycoplasma fermentans induced interleukin-6 production by human gingival fibroblasts. The active entities were divided into hydrophilic and hydrophobic substances. In this study, we purified a 4.1-kilodalton polypeptide from the hydrophilic substances. It reacted with polyclonal antibodies to M. fermentans and activated human macrophages.

* Corresponding author. Mailing address: Department of Oral Pathobiological Science, Graduate School of Dental Medicine, Hokkaido University, Nishi 7, Kita 13, Kita-ku, Sapporo 060-8586, Japan. Phone: 81-11-706 4242. Fax: 81-11-706 4901. E-mail: akkun{at}den.hokudai.ac.jp.

Infection and Immunity, November 2001, p. 7173-7177, Vol. 69, No. 11
0019-9567/01/$04.00+0   DOI: 10.1128/IAI.69.11.7173-7177.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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