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Infection and Immunity, November 2001, p. 7178-7181, Vol. 69, No. 11
0019-9567/01/$04.00+0   DOI: 10.1128/IAI.69.11.7178-7181.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Urethral Cytokine and Immune Responses in Chlamydia trachomatis-Infected Males

Mitchell S. Pate,^1,2,* Spencer R. Hedges,² Don A. Sibley,² Michael W. Russell,^2, Edward W. Hook III,^2,3 and Jiri Mestecky^1,4

Department of Microbiology¹ and Division of Infectious Diseases² and Division of Clinical Immunology and Rheumatology,⁴ Department of Medicine, The University of Alabama at Birmingham, and Jefferson County Department of Health,³ Birmingham, Alabama 35294

Received 11 May 2001/Returned for modification 7 June 2001/Accepted 25 July 2001

Penile urethral swabs collected from PCR-confirmed Chlamydia trachomatis-infected, C. trachomatis-uninfected, and non-C. trachomatis-infected, nongonococcal urethritis-infected males were analyzed for cytokine, total immunoglobulin (Ig), and specific antibody levels by enzyme-linked immunosorbent assay. Differential cellular components of the swab transport medium were also enumerated for the same groups. Although low, the levels of C. trachomatis-specific IgA and IgG antibodies and interleukin 8 cytokine were significantly higher in C. trachomatis-infected individuals. There were no significant differences in the levels of seven additional cytokines evaluated.

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^* Corresponding author. Mailing address: Department of Microbiology, The University of Alabama at Birmingham, BBRB Box 1, 845 19th St. S, Birmingham, AL 35294-2170. Phone: (205) 934-1737. Fax: (205) 934-3894. E-mail: mspate{at}uab.edu.

Present address: Department of Microbiology, University at Buffalo, Buffalo, NY 14214-3000.

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Infection and Immunity, November 2001, p. 7178-7181, Vol. 69, No. 11
0019-9567/01/$04.00+0   DOI: 10.1128/IAI.69.11.7178-7181.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

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