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 Previous Article

Infection and Immunity, November 2001, p. 7194-7196, Vol. 69, No. 11
0019-9567/01/$04.00+0   DOI: 10.1128/IAI.69.11.7194-7196.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Naturally Occurring Clostridium perfringens Nontoxic Alpha-Toxin Variant as a Potential Vaccine Candidate against Alpha-Toxin-Associated Diseases

Heike Schoepe,* Christian Pache, Axel Neubauer, Heidrun Potschka, Tobias Schlapp, Lothar H. Wieler,dagger and Georg Baljer

Institut für Hygiene und Infektionskrankheiten der Tiere, Justus-Liebig-Universität Giessen, D-35392 Giessen, Germany

Received 2 January 2001/Returned for modification 15 March 2001/Accepted 11 July 2001

Clostridium perfringens mutant strain 121A/91 shows neither enzymatic (phospholipase C) nor hemolytic activity. Nevertheless, the cpa gene and the corresponding alpha-toxin variant are detectable. Vaccination with this genetically constructed alpha-toxin variant, rAT121/91, induces antibodies capable of significantly reducing activities induced by wild-type toxin. Thus, rAT121/91 could be a useful vaccine candidate.

* Corresponding author. Mailing address: Institut für Hygiene und Infektionskrankheiten der Tiere, Justus-Liebig-Universität Giessen, Frankfurter Straße 85-87, D-35392 Giessen, Germany. Phone: 0049/641/9938307. Fax: 0049/641/9938309. E-mail: Heike.Schoepe{at}vetmed.uni-giessen.de.

dagger Present address: Institut für Mikrobiologie und Tierseuchen, Freie Universität Berlin, D-10115 Berlin, Germany.

Infection and Immunity, November 2001, p. 7194-7196, Vol. 69, No. 11
0019-9567/01/$04.00+0   DOI: 10.1128/IAI.69.11.7194-7196.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.




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Copyright © 2001 by the American Society for Microbiology. All rights reserved.