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Infection and Immunity, December 2001, p. 7753-7759, Vol. 69, No. 12
0019-9567/01/$04.00+0   DOI: 10.1128/IAI.69.12.7753-7759.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Chlamydia pneumoniae Infects and Multiplies in Lymphocytes In Vitro

Shusaku Haranaga,1 Hiroyuki Yamaguchi,1 Herman Friedman,1 Shin-ichi Izumi,2 and Yoshimasa Yamamoto1,*

Department of Medical Microbiology and Immunology, University of South Florida College of Medicine, Tampa, Florida 33612,1 and Department of Histology and Cell Biology, Nagasaki University School of Medicine, Nagasaki 852-8523, Japan2

Received 16 May 2001/Returned for modification 3 July 2001/Accepted 24 August 2001

The obligate intracellular pathogen Chlamydia (Chlamydophila) pneumoniae is known to be associated with some chronic inflammatory diseases, such as atherosclerosis. Interaction between C. pneumoniae and immune cells is important in the development of such diseases. However, susceptibility of immune cells, particularly lymphocytes, to C. pneumoniae infection has not been reported, even though lymphocytes play a pivotal role in the development of the diseases caused by this bacterium. In this regard, we examined the susceptibility of lymphocytes to C. pneumoniae infection in vitro. The results demonstrated that human peripheral blood lymphocytes as well as mouse spleen lymphocytes could be infected with C. pneumoniae. Furthermore, purified T lymphocytes as well as established T-lymphocyte cell line cells showed an obvious susceptibility to C. pneumoniae infection, indicating that T cells could be one of the host cells for this bacterial infection. These findings reveal a new infection site for C. pneumoniae, i.e., lymphocytes.

* Corresponding author. Mailing address: Department of Medical Microbiology and Immunology, University of South Florida College of Medicine, 12901 Bruce B. Downs Blvd., Tampa, FL 33612. Phone: (813) 974-2332. Fax: (813) 974-4151. E-mail: yyamamot{at}hsc.usf.edu.

Infection and Immunity, December 2001, p. 7753-7759, Vol. 69, No. 12
0019-9567/01/$04.00+0   DOI: 10.1128/IAI.69.12.7753-7759.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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