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Infection and Immunity, December 2001, p. 7894-7897, Vol. 69, No. 12
0019-9567/01/$04.00+0   DOI: 10.1128/IAI.69.12.7894-7897.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Koala Biovar of Chlamydia pneumoniae Infects Human and Koala Monocytes and Induces Increased Uptake of Lipids In Vitro

Katie A. Coles,1,2,* Peter Timms,3 and David W. Smith2,4

Departments of Public Health1 and Microbiology,2 the University of Western Australia, and Western Australian Centre for Pathology and Medical Research, Sir Charles Gairdner Hospital,4 Perth, and Centre for Molecular Biotechnology, School of Life Sciences, Queensland University of Technology, Brisbane,3 Australia

Received 23 April 2001/Returned for modification 13 June 2001/Accepted 6 September 2001

We examined the ability of the koala biovar of Chlamydia pneumoniae to infect both Hep-2 cells and human monocytes and the effect of infection on the formation of foam cells. The koala biovar produced large inclusions in both human and koala monocytes and in Hep-2 cells. Koala C. pneumoniae induced foam cell formation with and without added low-density lipoprotein, in contrast to TW183, which produced increased foam cell formation only in the presence of low-density lipoprotein.

* Corresponding author. Mailing address: International House, The University of Melbourne, Parkville, Victoria 3052, Australia. Phone: 61 3 9345 7365. Fax: 61 3 9349 1761. E-mail: k.coles{at}ugrad.unimelb.edu.au.

Infection and Immunity, December 2001, p. 7894-7897, Vol. 69, No. 12
0019-9567/01/$04.00+0   DOI: 10.1128/IAI.69.12.7894-7897.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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