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Infection and Immunity, December 2001, p. 7911-7914, Vol. 69, No. 12
0019-9567/01/$04.00+0   DOI: 10.1128/IAI.69.12.7911-7914.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Blockade of Caspases Inhibits Amebic Liver Abscess Formation in a Mouse Model of Disease

Le Yan and Samuel L. Stanley Jr.*

Departments of Medicine and Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri

Received 18 June 2001/Returned for modification 6 August 2001/Accepted 25 August 2001

We looked at the effect of inhibiting caspases on amebic liver abscess in the mouse model of infection. A dose of the pan-caspase inhibitor benzyloxycarbonyl-V-A-D-O-methyl fluoromethyl ketone (Z-VAD-FMK; R & D Systems) given to SCID mice 2 h prior to direct hepatic inoculation with Entamoeba histolytica trophozoites, and 12 h after amebic inoculation, reduced the mean liver abscess size by 70% at 24 h compared to a control group. These data indicate that apoptosis plays a significant but not an exclusive role in amebic liver abscess formation in the mouse model.

* Corresponding author. Mailing address: Department of Medicine, Division of Infectious Diseases, Campus Box 8051, Washington University School of Medicine, 660 S. Euclid Ave., St. Louis, MO 63110. Phone: (314) 362-1070. Fax: (314) 362-3525. E-mail: sstanley{at}im.wustl.edu.

Infection and Immunity, December 2001, p. 7911-7914, Vol. 69, No. 12
0019-9567/01/$04.00+0   DOI: 10.1128/IAI.69.12.7911-7914.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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Copyright © 2001 by the American Society for Microbiology. All rights reserved.