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Infection and Immunity, December 2001, p. 7915-7921, Vol. 69, No. 12
0019-9567/01/$04.00+0   DOI: 10.1128/IAI.69.12.7915-7921.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Infection of Synovial Fibroblasts in Culture by Yersinia enterocolitica and Salmonella enterica Serovar Enteritidis: Ultrastructural Investigation with Respect to the Pathogenesis of Reactive Arthritis

Almut Meyer-Bahlburg,1 Jörg Brinkhoff,1 Veit Krenn,2,dagger Karlheinz Trebesius,3 Jürgen Heesemann,3 and Hans-Iko Huppertz1,*

Children's Hospital1 and Institute of Pathology,2 University of Würzburg, D-97080 Würzburg, and Max von Pettenkofer Institut, University of Munich, D-80336 Munich,3 Germany

Received 29 March 2001/Returned for modification 28 May 2001/Accepted 24 July 2001

Synovial fibroblasts were infected with Yersinia enterocolitica or Salmonella enterica serovar Enteritidis and analyzed by electron microscopy and fluorescence in situ hybridization. Intracellular bacterial replication was followed by degradation leading to "ghosts" possessing lipopolysaccharides but not DNA. However, single bacteria survived for more than 2 weeks. Therefore, transient intra-articular infection might be the missing link between initial intestinal infection and late synovial inflammation in the pathogenesis of reactive arthritis.

* Corresponding author. Present address: Prof.-Hess-Kinderklinik, 28205 Bremen, Germany. Phone: 49 421/497 5410. Fax: 49 421/497 3311. E-mail: huppertz.bremen{at}t-online.de.

dagger Present address: Institute of Pathology, Charité, D-10117 Berlin, Germany.

Infection and Immunity, December 2001, p. 7915-7921, Vol. 69, No. 12
0019-9567/01/$04.00+0   DOI: 10.1128/IAI.69.12.7915-7921.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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