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Infection and Immunity, December 2001, p. 7946-7949, Vol. 69, No. 12
0019-9567/01/$04.00+0   DOI: 10.1128/IAI.69.12.7946-7949.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Multiple Overlapping Epitopes in the Repetitive Unit of the Shed Acute-Phase Antigen from Trypanosoma cruzi Enhance Its Immunogenic Properties

Paula Alvarez,1 M. Susana Leguizamón,2 Carlos A. Buscaglia,1 Tamara A. Pitcovsky,1 and Oscar Campetella1,*

Instituto de Investigaciones Biotecnológicas, Universidad Nacional de General San Martin1, and Departamento de Microbiologia, Facultad de Medicina, Universidad de Buenos Aires2, Buenos Aires, Argentina

Received 23 July 2001/Returned for modification 25 August 2001/Accepted 24 September 2001

The repetitive shed acute-phase antigen (SAPA) from Trypanosoma cruzi was thoroughly mapped by SPOT peptides and phage display strategies, showing that a single SAPA repeat is composed of multiple overlapping B-cell epitopes. We propose that this intricate antigenic structure constitutes an alternative device to repetitiveness in order to improve its immunogenicity.

* Corresponding author. Mailing address: Instituto de Investigaciones Biotecnológicas, Universidad Nacional de General San Martin, Predio INTI, Edificio 24, Av. Gral Paz y Constituyentes, (1650) San Martin, Buenos Aires, Argentina. Phone: 54-11-45807255 to -57. Fax: 54-11-47529639. E-mail: oscar{at}iib.unsam.edu.ar.

Infection and Immunity, December 2001, p. 7946-7949, Vol. 69, No. 12
0019-9567/01/$04.00+0   DOI: 10.1128/IAI.69.12.7946-7949.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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Copyright © 2001 by the American Society for Microbiology. All rights reserved.