This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Gibson, F. C.
Right arrow Articles by Genco, C. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Gibson, F. C., III
Right arrow Articles by Genco, C. A.

 Previous Article  |  Next Article 

Infection and Immunity, December 2001, p. 7959-7963, Vol. 69, No. 12
0019-9567/01/$04.00+0   DOI: 10.1128/IAI.69.12.7959-7963.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Prevention of Porphyromonas gingivalis-Induced Oral Bone Loss following Immunization with Gingipain R1

Frank C. Gibson III* and Caroline Attardo Genco

Department of Medicine, Section of Infectious Diseases, Boston University School of Medicine, Boston, Massachusetts 02118

Received 2 May 2001/Returned for modification 18 June 2001/Accepted 13 September 2001

The arginine gingipains RgpA and RgpB of Porphyromonas gingivalis are well-documented virulence factors of this organism. Structurally, RgpA and RgpB have nearly identical catalytic domains, while RgpA possesses an additional hemagglutinin domain. In this study, we examined the abilities of these proteins to elicit protection against P. gingivalis-mediated oral bone loss in a murine oral challenge model. Mice immunized subcutaneously with heat-killed P. gingivalis or purified RgpA or RgpB possessed elevated levels of P. gingivalis-specific immunoglobulin G; however, only the animals immunized with P. gingivalis whole cells or RgpA were protected from maxillary bone loss. These data suggest that immunization with RgpA stimulates the production of hemagglutinin domain-specific antibodies, which contribute to the prevention of P. gingivalis-mediated periodontal disease.


* Corresponding author. Mailing address: Department of Medicine, Section of Infectious Diseases, Boston University School of Medicine, 650 Albany Street, Boston, MA 02118. Phone: (617) 414-5258. Fax: (617) 414-5280. E-mail: frank.gibson{at}bmc.org.


Infection and Immunity, December 2001, p. 7959-7963, Vol. 69, No. 12
0019-9567/01/$04.00+0   DOI: 10.1128/IAI.69.12.7959-7963.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.



This article has been cited by other articles:

  • Lee, S. F., Andrian, E., Rowland, E., Marquez, I. C. (2009). Immune Response and Alveolar Bone Resorption in a Mouse Model of Treponema denticola Infection. Infect. Immun. 77: 694-698 [Abstract] [Full Text]  
  • Sathishkumar, S., Meka, A., Dawson, D., House, N., Schaden, W., Novak, M.J., Ebersole, J. L., Kesavalu, L. (2008). Extracorporeal Shock Wave Therapy Induces Alveolar Bone Regeneration. JDR 87: 687-691 [Abstract] [Full Text]  
  • Miyachi, K., Ishihara, K., Kimizuka, R., Okuda, K. (2007). Arg-gingipain A DNA Vaccine Prevents Alveolar Bone Loss in Mice. JDR 86: 446-450 [Abstract] [Full Text]  
  • Teng, Y.-T.A. (2006). Protective and Destructive Immunity in the Periodontium: Part 2--T-cell-mediated Immunity in the Periodontium. JDR 85: 209-219 [Abstract] [Full Text]  
  • Miyamoto, T., Yumoto, H., Takahashi, Y., Davey, M., Gibson, F. C. III, Genco, C. A. (2006). Pathogen-Accelerated Atherosclerosis Occurs Early after Exposure and Can Be Prevented via Immunization. Infect. Immun. 74: 1376-1380 [Abstract] [Full Text]  
  • Gibson, F. C. III, Hong, C., Chou, H.-H., Yumoto, H., Chen, J., Lien, E., Wong, J., Attardo Genco, C. (2004). Innate Immune Recognition of Invasive Bacteria Accelerates Atherosclerosis in Apolipoprotein E-Deficient Mice. Circulation 109: 2801-2806 [Abstract] [Full Text]  
  • Gibson, F. C. III, Gonzalez, D. A., Wong, J., Genco, C. A. (2004). Porphyromonas gingivalis-Specific Immunoglobulin G Prevents P. gingivalis-Elicited Oral Bone Loss in a Murine Model. Infect. Immun. 72: 2408-2411 [Abstract] [Full Text]  
  • Gyurko, R., Boustany, G., Huang, P. L., Kantarci, A., Van Dyke, T. E., Genco, C. A., Gibson, F. C. III (2003). Mice Lacking Inducible Nitric Oxide Synthase Demonstrate Impaired Killing of Porphyromonas gingivalis. Infect. Immun. 71: 4917-4924 [Abstract] [Full Text]  
  • Kuramitsu, H. K. (2003). MOLECULAR GENETIC ANALYSIS OF THE VIRULENCE OF ORAL BACTERIAL PATHOGENS: AN HISTORICAL PERSPECTIVE. CROBM 14: 331-344 [Abstract] [Full Text]  
  • Gonzalez, D., Tzianabos, A. O., Genco, C. A., Gibson III, F. C. (2003). Immunization with Porphyromonas gingivalis Capsular Polysaccharide Prevents P. gingivalis-Elicited Oral Bone Loss in a Murine Model. Infect. Immun. 71: 2283-2287 [Abstract] [Full Text]  
  • Rajapakse, P. S., O'Brien-Simpson, N. M., Slakeski, N., Hoffmann, B., Reynolds, E. C. (2002). Immunization with the RgpA-Kgp Proteinase-Adhesin Complexes of Porphyromonas gingivalis Protects against Periodontal Bone Loss in the Rat Periodontitis Model. Infect. Immun. 70: 2480-2486 [Abstract] [Full Text]