This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Robinson, P.
Right arrow Articles by White, A. C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Robinson, P.
Right arrow Articles by White, A. C., Jr.

 Previous Article  |  Next Article 

Infection and Immunity, February 2001, p. 1172-1174, Vol. 69, No. 2
0019-9567/01/$04.00+0   DOI: 10.1128/IAI.69.2.1172-1174.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Expression of Tumor Necrosis Factor Alpha and Interleukin 1beta in Jejuna of Volunteers after Experimental Challenge with Cryptosporidium parvum Correlates with Exposure but Not with Symptoms

Prema Robinson,1,2 Pablo C. Okhuysen,3,4 Cynthia L. Chappell,4 Dorothy E. Lewis,5 Imran Shahab,6 Andrzej Janecki,3 and A. Clinton White Jr.1,2,*

Departments of Medicine,1 Immunology,5 Molecular Virology and Microbiology,2 and Pathology,6 Baylor College of Medicine, and Department of Medicine3 and School of Public Health,4 University of Texas Health Sciences Center, Houston, Texas 77030

Received 7 September 2000/Accepted 14 November 2000

Jejunal biopsies from volunteers challenged with Cryptosporidium parvum were examined for tumor necrosis factor alpha (TNF-alpha ) and interleukin (IL)-1beta mRNA. Postchallenge biopsies from 15 of 28 (54%) volunteers expressed TNF-alpha ; 14% expressed IL-1beta . Cytokine expression did not correlate with enteric symptoms, suggesting that TNF-alpha and IL-1beta are not key mediators of diarrhea in human cryptosporidiosis.

* Corresponding author. Mailing address: Infectious Diseases Section, Department of Medicine, Baylor College of Medicine, One Baylor Plaza, Room 561E, Houston, TX 77030. Fax: (713) 790-0681. E-mail: arthurw{at}bcm.tmc.edu.

Infection and Immunity, February 2001, p. 1172-1174, Vol. 69, No. 2
0019-9567/01/$04.00+0   DOI: 10.1128/IAI.69.2.1172-1174.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:

  • Pantenburg, B., Dann, S. M., Wang, H.-C., Robinson, P., Castellanos-Gonzalez, A., Lewis, D. E., White, A. C. Jr. (2008). Intestinal Immune Response to Human Cryptosporidium sp. Infection. Infect. Immun. 76: 23-29 [Full Text]  
  • Lean, I-S., Lacroix-Lamande, S., Laurent, F., McDonald, V. (2006). Role of Tumor Necrosis Factor Alpha in Development of Immunity against Cryptosporidium parvum Infection. Infect. Immun. 74: 4379-4382 [Abstract] [Full Text]  
  • Zaalouk, T. K., Bajaj-Elliott, M., George, J. T., McDonald, V. (2004). Differential Regulation of {beta}-Defensin Gene Expression during Cryptosporidium parvum Infection. Infect. Immun. 72: 2772-2779 [Abstract] [Full Text]  
  • ALCANTARA, C. S., YANG, C.-H., STEINER, T. S., BARRETT, L. J., LIMA, A. A. M., CHAPPELL, C. L., OKHUYSEN, P. C., WHITE, A. C. JR., GUERRANT, R. L. (2003). INTERLEUKIN-8, TUMOR NECROSIS FACTOR-{alpha}, AND LACTOFERRIN IN IMMUNOCOMPETENT HOSTS WITH EXPERIMENTAL AND BRAZILIAN CHILDREN WITH ACQUIRED CRYPTOSPORIDIOSIS. Am J Trop Med Hyg 68: 325-328 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»