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*Cystic Fibrosis

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Infection and Immunity, February 2001, p. 1185-1188, Vol. 69, No. 2
0019-9567/01/$04.00+0   DOI: 10.1128/IAI.69.2.1185-1188.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Sera from Adult Patients with Cystic Fibrosis Contain Antibodies to Pseudomonas aeruginosa Type III Apparatus

Joel Moss,1 Mary E. Ehrmantraut,1 Bruce D. Banwart,2 Dara W. Frank,3 and Joseph T. Barbieri3,*

Pulmonary-Critical Care Medicine Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland,1 and Department of Pediatrics2 and Department of Microbiology and Molecular Genetics,3 Medical College of Wisconsin, Milwaukee, Wisconsin 53226

Received 14 July 2000/Returned for modification 11 September 2000/Accepted 19 October 2000

Expression of type III proteins of Pseudomonas aeruginosa in patients with cystic fibrosis (CF) was investigated by measuring the immune response against components of the type III pathway. Twenty-three of the 33 sera contained antibodies against PcrV, a protein involved in translocation of type III cytotoxins into eukaryotic cells, and 11 of 33 had antibodies against ExoS, while most CF sera contained antibodies against PopB and PopD, components of the type III apparatus. These data indicate that P. aeruginosa commonly expresses components of the type III translocation apparatus in adult CF patients.

* Corresponding author. Mailing address: Department of Microbiology and Molecular Genetics, Medical College of Wisconsin, 8701 Watertown Plank Rd., Milwaukee, WI 53226. Phone: (414) 456-8412. Fax: (414) 456-6535. E-mail: toxin{at}mcw.edu.

Infection and Immunity, February 2001, p. 1185-1188, Vol. 69, No. 2
0019-9567/01/$04.00+0   DOI: 10.1128/IAI.69.2.1185-1188.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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