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Infection and Immunity, February 2001, p. 1189-1191, Vol. 69, No. 2
0019-9567/01/$04.00+0   DOI: 10.1128/IAI.69.2.1189-1191.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Capsular Reactions of Cryptococcus neoformans with Polyspecific and Oligospecific Polyclonal Anticapsular Antibodies

Tracy C. MacGill,1,2,dagger Randall S. MacGill,1 and Thomas R. Kozel1,2,*

Department of Microbiology1 and Cell and Molecular Biology Program,2 School of Medicine, University of Nevada, Reno, Nevada 89557

Received 10 August 2000/Returned for modification 25 September 2000/Accepted 2 November 2000

Monoclonal antibodies to the capsular polysaccharide of Cryptococcus neoformans produce distinct capsular reactions and have biological activities that are determined by serotype specificity. In the present study, polyclonal rabbit anticapsular antibodies were cross-absorbed to produce serotype specificities similar to those of monoclonal antibodies. The results showed that polyclonal and monoclonal antibodies with similar serotype specificities have similar capsular reactions and biological activities.

* Corresponding author. Mailing address: Department of Microbiology/320, School of Medicine, University of Nevada, Reno, NV 89557. Phone: (775) 784-4124. Fax: (775) 784-1620. E-mail: trkozel{at}med.unr.edu.

dagger Present address: Department of Immunology, Walter Reed Army Institute of Research, Silver Spring, MD 20910.

Infection and Immunity, February 2001, p. 1189-1191, Vol. 69, No. 2
0019-9567/01/$04.00+0   DOI: 10.1128/IAI.69.2.1189-1191.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:

  • Kozel, T. R., Thorkildson, P., Brandt, S., Welch, W. H., Lovchik, J. A., AuCoin, D. P., Vilai, J., Lyons, C. R. (2007). Protective and Immunochemical Activities of Monoclonal Antibodies Reactive with the Bacillus anthracis Polypeptide Capsule. Infect. Immun. 75: 152-163 [Abstract] [Full Text]  
  • Zaragoza, O., Casadevall, A. (2004). Antibodies Produced in Response to Cryptococcus neoformans Pulmonary Infection in Mice Have Characteristics of Nonprotective Antibodies. Infect. Immun. 72: 4271-4274 [Abstract] [Full Text]  
  • Brandt, S., Thorkildson, P., Kozel, T. R. (2003). Monoclonal Antibodies Reactive with Immunorecessive Epitopes of Glucuronoxylomannan, the Major Capsular Polysaccharide of Cryptococcus neoformans. CVI 10: 903-909 [Abstract] [Full Text]  


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