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Infection and Immunity, February 2001, p. 1192-1198, Vol. 69, No. 2
0019-9567/01/$04.00+0   DOI: 10.1128/IAI.69.2.1192-1198.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Expression, Extracellular Secretion, and Immunogenicity of the Plasmodium falciparum Sporozoite Surface Protein 2 in Salmonella Vaccine Strains

Oscar G. Gómez-Duarte,1 Marcela F. Pasetti,1 Araceli Santiago,1,2 Marcelo B. Sztein,1 Stephen L. Hoffman,3 and Myron M. Levine*

Center for Vaccine Development, Department of Medicine, School of Medicine, University of Maryland, Baltimore, Maryland 212011; Instituto de Ciencias Biomédicas, Universidad Autónoma de México, México City, México2; and Malaria Program, Naval Medical Research Center, Rockville, Maryland 208523

Received 31 August 1999/Returned for modification 3 October 1999/Accepted 6 November 2000

Deleting transmembrane alpha -helix motifs from Plasmodium falciparum sporozoite surface protein (SSP-2) allowed its secretion from Salmonella enterica serovar Typhimurium SL3261 and S. enterica serovar Typhi CVD 908-htrA by the Hly type I secretion system. In mice immunized intranasally, serovar Typhimurium constructs secreting SSP-2 stimulated greater gamma interferon splenocyte responses than did nonsecreting constructs (P = 0.04).

* Corresponding author. Mailing address: Center for Vaccine Development, University of Maryland School of Medicine, 685 West Baltimore St., Room 480, Baltimore, MD 21201. Phone: (410) 706- 7588. Fax: (410)706-6205. E-mail: mlevine{at}medicine.umaryland.edu.

Infection and Immunity, February 2001, p. 1192-1198, Vol. 69, No. 2
0019-9567/01/$04.00+0   DOI: 10.1128/IAI.69.2.1192-1198.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:

  • Chinchilla, M., Pasetti, M. F., Medina-Moreno, S., Wang, J. Y., Gomez-Duarte, O. G., Stout, R., Levine, M. M., Galen, J. E. (2007). Enhanced Immunity to Plasmodium falciparum Circumsporozoite Protein (PfCSP) by Using Salmonella enterica Serovar Typhi Expressing PfCSP and a PfCSP-Encoding DNA Vaccine in a Heterologous Prime-Boost Strategy. Infect. Immun. 75: 3769-3779 [Abstract] [Full Text]  
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