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Infection and Immunity, February 2001, p. 1199-1201, Vol. 69, No. 2
0019-9567/01/$04.00+0   DOI: 10.1128/IAI.69.2.1199-1201.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Mechanisms Mediating Porphyromonas gingivalis Gingipain RgpA-Induced Oral Mucosa Inflammation In Vivo

Israel Rubinstein,1,2,* Jan Potempa,3 James Travis,4 and Xiao-Pei Gao1

Departments of Medicine1 and Pharmaceutics and Pharmacodynamics,2 University of Illinois at Chicago and VA Chicago Health Care System West Side Division, Chicago, Illinois 60612; Department of Microbiology, Institute of Molecular Biology, Tagiellonian University, Krakow, Poland3; and Department of Biochemistry and Molecular Biology, University of Georgia, Athens, Georgia 306024

Received 6 July 2000/Returned for modification 14 September 2000/Accepted 16 November 2000

Suffusion of gingipain RgpA (GRgpA) elicited a significant concentration-dependent increase in the clearance of macromolecules from in situ hamster cheek pouch which was attenuated by NPC 17647, a selective bradykinin B2 receptor antagonist. Leupeptin and a mixture of proteinase inhibitors also attenuated GRgpA-induced responses. These data indicate that GRgpA elicits plasma exudation from in situ oral mucosa in a catalytic site-dependent fashion by elaborating bradykinin.

* Corresponding author. Mailing address: Department of Medicine (M/C 787), University of Illinois at Chicago, 840 South Wood St., Chicago, IL 60612-7323. Phone: (312) 996-8039. Fax: (312) 996-4665. E-mail: IRubinst{at}uic.edu.

Infection and Immunity, February 2001, p. 1199-1201, Vol. 69, No. 2
0019-9567/01/$04.00+0   DOI: 10.1128/IAI.69.2.1199-1201.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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