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Infection and Immunity, February 2001, p. 1207-1211, Vol. 69, No. 2
0019-9567/01/$04.00+0   DOI: 10.1128/IAI.69.2.1207-1211.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Differential Patterns of Human Immunoglobulin G Subclass Responses to Distinct Regions of a Single Protein, the Merozoite Surface Protein 1 of Plasmodium falciparum

David R. Cavanagh,1,* Carlota Dobaño,1 Ibrahim M. Elhassan,2 Kevin Marsh,3 Ahmed Elhassan,2 Lars Hviid,4 E. At Tahir G. Khalil,2 Thor G. Theander,4 David E. Arnot,1 and Jana S. McBride1

Institute of Cell, Animal and Population Biology, Division of Biological Sciences, University of Edinburgh, Edinburgh EH9 3JT, Scotland1; Institute of Endemic Diseases, University of Khartoum, Khartoum, Sudan2; KEMRI Centre for Geographic Medicine Research Coast, Kilifi, Kenya3; and Centre for Medical Parasitology, Institute of Medical Microbiology and Immunology, University of Copenhagen, and Department of Infectious Diseases, Copenhagen University Hospital, Copenhagen, Denmark4

Received 28 February 2000/Returned for modification 11 April 2000/Accepted 26 October 2000

Comparisons of immunoglobulin G (IgG) subclass responses to the major polymorphic region and to a conserved region of MSP-1 in three cohorts of African villagers exposed to Plasmodium falciparum revealed that responses to Block 2 are predominantly IgG3 whereas antibodies to MSP-119 are mainly IgG1. The striking dominance of IgG3 to Block 2 may explain the short duration of this response and also the requirement for continuous stimulation by malaria infection to maintain clinical immunity.

* Corresponding author. Mailing address: Institute of Cell, Animal and Population Biology, Division of Biological Sciences, University of Edinburgh, King's Buildings, West Mains Rd., Edinburgh EH9 3JT, Scotland, United Kingdom. Phone: (44) 131-650-5459. Fax: (44) 131-650-7322. E-mail: cavanagh{at}srv0.bio.ed.ac.uk.

Infection and Immunity, February 2001, p. 1207-1211, Vol. 69, No. 2
0019-9567/01/$04.00+0   DOI: 10.1128/IAI.69.2.1207-1211.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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