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Infection and Immunity, February 2001, p. 1212-1214, Vol. 69, No. 2
0019-9567/01/$04.00+0   DOI: 10.1128/IAI.69.2.1212-1214.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

T Cells That React to the Immunodominant Leishmania major LACK Antigen Prevent Early Dissemination of the Parasite in Susceptible BALB/c Mice

Sabrina Schilling and Nicolas Glaichenhaus*

Centre National de la Recherche Scientifique, Institut de Pharmacologie Moléculaire et Cellulaire, 06560 Valbonne, France

Received 17 July 2000/Returned for modification 6 September 2000/Accepted 28 October 2000

Susceptibility of BALB/c mice to Leishmania major depends on the early production of IL-4 by CD4+ T cells which react to the parasite LACK antigen. Here, we show that LACK-specific cells are rapidly recruited to the site of infection and favor the early dissemination of L. major to the internal organs.

* Corresponding author. Mailing address: Centre National de la Recherche Scientifique, Institut de Pharmacologie Moléculaire et Cellulaire, 660 Route des Lucioles, 06560 Valbonne, France. Phone: 33-4-93-95-77-85. Fax: 33-4-93-95-77-08. E-mail: glaichenhaus{at}ipmc.cnrs.fr.

Infection and Immunity, February 2001, p. 1212-1214, Vol. 69, No. 2
0019-9567/01/$04.00+0   DOI: 10.1128/IAI.69.2.1212-1214.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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  • Lange, U. G., Mastroeni, P., Blackwell, J. M., Stober, C. B. (2004). DNA-Salmonella enterica Serovar Typhimurium Primer-Booster Vaccination Biases towards T Helper 1 Responses and Enhances Protection against Leishmania major Infection in Mice. Infect. Immun. 72: 4924-4928 [Abstract] [Full Text]  


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